Paper $30.00 ISBN: 9780226546087 Published April 2018
Cloth $90.00 ISBN: 9780226545929 Published April 2018
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Model Behavior

Animal Experiments, Complexity, and the Genetics of Psychiatric Disorders

Nicole C. Nelson

Model Behavior

Nicole C. Nelson

272 pages | 3 halftones, 3 line drawings, 1 table | 6 x 9 | © 2018
Paper $30.00 ISBN: 9780226546087 Published April 2018
Cloth $90.00 ISBN: 9780226545929 Published April 2018
E-book $10.00 to $30.00 About E-books ISBN: 9780226546117 Published April 2018
Mice are used as model organisms across a wide range of fields in science today—but it is far from obvious how studying a mouse in a maze can help us understand human problems like alcoholism or anxiety. How do scientists convince funders, fellow scientists, the general public, and even themselves that animal experiments are a good way of producing knowledge about the genetics of human behavior? In Model Behavior, Nicole C. Nelson takes us inside an animal behavior genetics laboratory to examine how scientists create and manage the foundational knowledge of their field.

Behavior genetics is a particularly challenging field for making a clear-cut case that mouse experiments work, because researchers believe that both the phenomena they are studying and the animal models they are using are complex. These assumptions of complexity change the nature of what laboratory work produces. Whereas historical and ethnographic studies traditionally portray the laboratory as a place where scientists control, simplify, and stabilize nature in the service of producing durable facts, the laboratory that emerges from Nelson’s extensive interviews and fieldwork is a place where stable findings are always just out of reach. The ongoing work of managing precarious experimental systems means that researchers learn as much—if not more—about the impact of the environment on behavior as they do about genetics. Model Behavior offers a compelling portrait of life in a twenty-first-century laboratory, where partial, provisional answers to complex scientific questions are increasingly the norm.
Contents
Introduction: A Furry, One-Ounce Human?
1 Containing Complexities in the Animal Behavior Genetics Laboratory
2 Animal Behavior Genetics, the Past and the Future
3 Building Epistemic Scaffolds for Modeling Work
4 Epistemic By-Products: Learning about Environments while Studying Genetics
5 Understanding Binge Drinking
6 Leaving the Laboratory
Conclusion: An Expanded Vocabulary for the Laboratory
Acknowledgments
Appendix
Notes
Bibliography
Review Quotes
New Scientist
“Scientists are accustomed to investigating the natural world and to drawing conclusions about it. In Model Behavior, historian of science Nicole Nelson turns the spotlight on them for a change. Like an anthropologist facing a new tribe, Nelson focuses her keen analytical mind on a US team researching the genetics of alcoholism in mice. The result is a stimulating and challenging exploration of science, and of how social scientists think about science. Everybody wins.”
For more information, or to order this book, please visit https://www.press.uchicago.edu
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