University of Chicago Press: New Titles in Medical Science

Longevity Seekers

Ted Anton — Wed, 01 May 2013 05:00:00 GMT

People have searched for the fountain of youth everywhere from Bimini to St. Augustine. But for a steadfast group of scientists, the secret to a long life lies elsewhere: in the lowly lab worm. By suppressing the function of just a few key genes, these scientists were able to lengthen worms’ lifespans up to tenfold, while also controlling the onset of many of the physical problems that beset old age. As the global population ages, the potential impact of this discovery on society is vast—as is the potential for profit.

With The Longevity Seekers, science writer Ted Anton takes readers inside this tale that began with worms and branched out to snare innovative minds from California to Crete, investments from big biotech, and endorsements from TV personalities like Oprah and Dr. Oz. Some of the research was remarkable, such as the discovery of an enzyme in humans that stops cells from aging. And some, like an oft-cited study touting the compound resveratrol, found in red wine—proved highly controversial, igniting a science war over truth, credit, and potential profit. As the pace of discovery accelerated, so too did powerful personal rivalries and public fascination, driven by the hope that a longer, healthier life was right around the corner. Anton has spent years interviewing and working with the scientists at the frontier of longevity science, and this book offers a behind-the-scenes look at the state-of-the-art research and the impact it might have on global public health, society, and even our friends and family.

With spectacular science and an unforgettable cast of characters, The Longevity Seekers has all the elements of a great story and sheds light on discoveriesthat could fundamentally reshape human life.

Unequal Health

Danny Dorling — Mon, 15 Apr 2013 05:00:00 GMT

Health inequalities are the most important inequalities of all, and in the United States and United Kingdom they have reached a formidable size. In this new book from provocative critic Daniel Dorling, health inequalities are held up as the scandal of our times. While health is generally better now than it was a century ago, the gaps in life expectancy between regions, cities—even neighborhoods—have surpassed the worst measures recorded over the past century. Drawing on international studies, annotated lectures, newspaper articles, and interviews, Dorling provides an authoritative critique of this egregious social problem, calling for immediate action against an injustice that any leading nation should be ashamed to allow.

Knowledge in the Time of Cholera

Owen Whooley — Thu, 11 Apr 2013 05:00:00 GMT

Vomiting. Diarrhea. Dehydration. Death. Confusion. In 1832, the arrival of cholera in the United States created widespread panic throughout the country. For the rest of the century, epidemics swept through American cities and towns like wildfire, killing thousands. Physicians of all stripes offered conflicting answers to the cholera puzzle, ineffectively responding with opiates, bleeding, quarantines, and all manner of remedies, before the identity of the dreaded infection was consolidated under the germ theory of disease some sixty years later.

These cholera outbreaks raised fundamental questions about medical knowledge and its legitimacy, giving fuel to alternative medical sects that used the confusion of the epidemic to challenge both medical orthodoxy and the authority of the still-new American Medical Association. In Knowledge in the Time of Cholera, Owen Whooley tells us the story of those dark days, centering his narrative on rivalries between medical and homeopathic practitioners and bringing to life the battle to control public understanding of disease, professional power, and democratic governance in nineteenth-century America.

Nazi Symbiosis

Sheila Faith Weiss — Thu, 04 Apr 2013 05:00:00 GMT

The Faustian bargain—in which an individual or group collaborates with an evil entity in order to obtain knowledge, power, or material gain—is perhaps best exemplified by the alliance between world-renowned human geneticists and the Nazi state. Under the swastika, German scientists descended into the moral abyss, perpetrating heinous medical crimes at Auschwitz and at euthanasia hospitals. But why did biomedical researchers accept such a bargain?

The Nazi Symbiosis offers a nuanced account of the myriad ways human heredity and Nazi politics reinforced each other before and during the Third Reich. Exploring the ethical and professional consequences for the scientists involved as well as the political ramifications for Nazi racial policies, Sheila Faith Weiss places genetics and eugenics in their larger international context. In questioning whether the motives that propelled German geneticists were different from the compromises that researchers from other countries and eras face, Weiss extends her argument into our modern moment, as we confront the promises and perils of genomic medicine today.

Genomes and What to Make of Them

Barry Barnes; John Dupré — Tue, 02 Apr 2013 05:00:00 GMT

The announcement in 2003 that the Human Genome Project had completed its map of the entire human genome was heralded as a stunning scientific breakthrough: our first full picture of the basic building blocks of human life. Since then, boasts about the benefits—and warnings of the dangers—of genomics have remained front-page news, with everyone agreeing that genomics has the potential to radically alter life as we know it.

For the nonscientist, the claims and counterclaims are dizzying—what does it really mean to understand the genome? Barry Barnes and John Dupré offer an answer to that question and much more in Genomes and What to Make of Them, a clear and lively account of the genomic revolution and its promise. The book opens with a brief history of the science of genetics and genomics, from Mendel to Watson and Crick and all the way up to Craig Venter; from there the authors delve into the use of genomics in determining evolutionary paths—and what it can tell us, for example, about how far we really have come from our ape ancestors. Barnes and Dupré then consider both the power and risks of genetics, from the economic potential of plant genomes to overblown claims that certain human genes can be directly tied to such traits as intelligence or homosexuality. Ultimately, the authors argue, we are now living with a new knowledge as powerful in its way as nuclear physics, and the stark choices that face us—between biological warfare and gene therapy, a new eugenics or a new agricultural revolution—will demand the full engagement of both scientists and citizens.

Written in straightforward language but without denying the complexity of the issues, Genomes and What to Make of Them is both an up-to-date primer and a blueprint for the future.

Panaceia's Daughters

Alisha Rankin — Tue, 19 Mar 2013 05:00:00 GMT

Panaceia’s Daughters provides the first book-length study of noblewomen’s healing activities in early modern Europe. Drawing on rich archival sources, Alisha Rankin demonstrates that numerous German noblewomen were deeply involved in making medicines and recommending them to patients, and many gained widespread fame for their remedies. Turning a common historical argument on its head, Rankin maintains that noblewomen’s pharmacy came to prominence not in spite of their gender but because of it.

Rankin demonstrates the ways in which noblewomen’s pharmacy was bound up in notions of charity, class, religion, and household roles, as well as in expanding networks of knowledge and early forms of scientific experimentation. The opening chapters place noblewomen’s healing within the context of cultural exchange, experiential knowledge, and the widespread search for medicinal recipes in early modern Europe. Case studies of renowned healers Dorothea of Mansfeld and Anna of Saxony then demonstrate the value their pharmacy held in their respective roles as elderly widow and royal consort, while a study of the long-suffering Duchess Elisabeth of Rochlitz emphasizes the importance of experiential knowledge and medicinal remedies to the patient’s experience of illness.

Can Onions Cure Ear-Ache?

William Buchan; Melanie King — Fri, 15 Mar 2013 05:00:00 GMT

What common condition was once treated with cow dung? How might oyster shells relieve heartburn? Can eels really cure deafness? Is the secret to stopping a stubborn case of hiccups a simple ingredient found in most pantries? If you were struck by illness or injury in the late eighteenth century, you would most likely have been referred to Scottish physician William Buchan’s Domestic Medicine—and, as a result, you may have found yourself administering urine to your ears or drinking a broth made from sheep’s brains.

Originally published in 1769, Domestic Medicine was produced for the benefit of those without access to—or means to afford—medical assistance, and copies of the book were found in apothecaries and coffee houses, private households and clubs. In 1797, Bounty mutineer Fletcher Christian and his crew even had the foresight to pack a copy before fleeing to the Pitcairns. Derived from folklore and the emerging medical science of the day, some of Buchan’s recommendations for how to live a healthy life still ring true: for instance, exercising, enjoying a varied diet, and getting an abundance of fresh air. Others are delightfully dodgy or even downright dangerous, such as genital trusses, the prescription of mercury, or the suggestion that Spanish fly might soothe aching joints.

Bringing together an exceedingly entertaining selection of entries from one of the earliest self-help books, Can Onions Cure Ear-ache? offers fascinating insight into the popular treatments of the time.