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This book investigates the governance structures and mechanisms of knowledge and technology transfer in the context of innovation and production systems in six regions of Europe. For that purpose, the author develops a new and innovative heuristic governance model of knowledge transfer systems. Against the assumption of far-reaching institutional coherence and homogeneity of national systems in existing scholarship, Michael Ortiz demonstrates that national innovation and production systems are regionally variegated. With analyses of strengths and weaknesses, barriers, shortcomings, and dilemmas of regional innovation and knowledge transfer systems, the book ultimately identifies best practice models and policy recommendations for the investigated regions.