CHICAGO (June 12, 2012) – A small cluster of unusual illnesses at a Colorado children’s hospital prompted an investigation that swiftly identified alcohol prep pads contaminated with Bacillus cereus bacteria, according to a report in the July issue of Infection Control and Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America. The investigation ultimately led to an international recall of the contaminated products.
“At Children’s Hospital Colorado, three patients in the fall of 2010 were seriously ill and had positive cultures of an unusual nature, in this case, cultures associated with Bacillus cereus,” said Susan Dolan, RN, MS, CIC, a certified infection control nurse and one of the investigators.
A spore-forming, gram-positive bacteria, Bacillus cereus are historically known to cause food poisoning, but can also cause more serious infections, especially in people with weakened immune systems. The bacteria are capable of surviving in alcohol solutions.
The illnesses prompted an immediate investigation by the hospital’s infection prevention and control team and microbiology laboratory. The investigators focused on time, place, persons, procedures, equipment, and products that may have been common to each case. They found three products with which each patient had contact: a solution and device used to disinfect the skin before invasive procedures, a saline solution used to flush intravenous (IV) catheters, and alcohol prep pads that have a variety of uses in healthcare such as disinfecting the cap on an IV catheter.
Within days, lab tests showed B. cereus and other Bacillus species growing from the prep pads, prompting an immediate recall of the product throughout the pediatric healthcare system. The investigators notified the Colorado Department of Public Health and Environment and the Food and Drug Administration of their findings. Both agencies confirmed that the prep pads were contaminated with Bacillus on the outside and inside of the package. The investigation ultimately led to an international recall of the contaminated wipes and the eventual discontinuation of the brand identified in the case.
“Alcohol prep pads are among one of the most widely used products in healthcare, but are not always sterile products,” Dolan said. “Many healthcare facilities were using these pads but were not aware they were non-sterile because they were not labeled as such.”
As a result of the investigation, Children’s Hospital Colorado now uses only prep pads explicitly labeled as sterile. The researchers suggest regulations requiring clear labeling on such products.
Susan A. Dolan, Cynthia Littlehorn, Mary P. Glodé, Elaine Dowell, Karen Xavier, Ann-Christine Nyquist, and James K. Todd, “Association of Bacillus cereus Infection with Contaminated Alcohol Prep Pads.” Infection Control and Hospital Epidemiology 33:7 (July 2012).
Published through a partnership between the Society for Healthcare Epidemiology of America and The University of Chicago Press, Infection Control and Hospital Epidemiology provides original, peer-reviewed scientific articles for anyone involved with an infection control or epidemiology program in a hospital or healthcare facility. ICHE is ranked 15 out of 140 journals in its discipline in the latest Journal Citation Reports from Thomson Reuters.
SHEA is a professional society representing more than 1,900 physicians and other healthcare professionals around the world with expertise in healthcare epidemiology and infection prevention and control. SHEA's mission is to prevent and control healthcare-associated infections and advance the field of healthcare epidemiology. The society leads this field by promoting science and research and providing high-quality education and training in epidemiologic methods and prevention strategies. SHEA upholds the value and critical contributions of healthcare epidemiology to improving patient care and healthcare worker safety in all healthcare settings www.shea-online.org.